4.8 The Endomembrane System The endomembrane system includes rough and smooth endoplasmic reticulum (ER), vesicles, and Golgi bodies This system makes and modifies lipids and proteins; it also recycles and disposes of molecules and particles endomembrane system Series of interacting organelles (endoplasmic reticulum, Golgi bodies, vesicles) between nucleus and plasma membrane; produces lipids, proteins