Isabella I (Spanish: Isabel I) (Madrigal de las Altas Torres, Ávila, April 22, 1451 – November 26, 1504 in Medina del Campo, Valladolid) was Queen of Castile and León. She is considered one of the most important sovereigns in world history. escuela flamenca (??). Atribuida a Gerard David (??). Anónimo flamenco (del Círculo de Jan Gossaert).