Extracellular matrix (ECM) is an extensive molecule network composed of three major components: protein, glycosaminoglycan, and glycoconjugate. ECM components, as well as cell adhesion receptors, interact with each other forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, proliferation, migration, differentiation, and some vital role in…