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NIH 3D Print Exchange - allows you to import from PDB or upload your own structure files; also has a trove of custom lab equipment designs. Ridiculously useful site if you have a 3D printer on hand.
MUSCLE is one of the best-performing multiple alignment programs according to published benchmark tests, with accuracy and speed that are consistently better than CLUSTALW. MUSCLE can align hundreds of sequences in seconds. Most users learn everything they need to know about MUSCLE in a few minutes—only a handful of command-line options are needed to perform common alignment tasks.
Exome Variant Server (EVS) - The goal of the NHLBI GO Exome Sequencing Project (ESP) is to discover novel genes and mechanisms contributing to heart, lung and blood disorders by pioneering the application of next-generation sequencing of the protein coding regions of the human genome across diverse, richly-phenotyped populations and to share these datasets and findings with the scientific community to extend and enrich the diagnosis, management and treatment of heart, lung and blood…
ExAC Browser - The Exome Aggregation Consortium (ExAC) is a coalition of investigators seeking to aggregate and harmonize exome sequencing data from a wide variety of large-scale sequencing projects, and to make summary data available for the wider scientific community.
GPCRDB - great site for generating diagrams, and also annotating or searching for mutants via B-W#
Document to Structure - Extract chemical info from patents via Marvin suite
OSRA: Optical Structure Recognition - convert images of chemical structures into SMILES